p-Toluenesulfonic acid monohydrate → HCID 86756909, compound

Participants

Reaction Steps

A solution of 0.288 g of (E)-2(R)-[1(S)-(tetrahydro-2(RS)-pyranyloxy)-carbamoyl]-4-phenyl-3-butenyl]-2′-isobutyl-4-methyl-2′-(D-phenylalanyl)valerohydrazide in 3 ml of methanol was treated with 0.099 g of p-toluenesulphonic acid monohydrate. The mixture was stirred for 3 hours at room temperature and evaporated. The residue was triturated with diethyl ether and then with hexane, filtered off and dried to give 0.232 g of (E)-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenyl-3-butenyl]-2′-isobutyl-4-methyl-2′-(D-phenylalanyl)valerohydrazide p-toluenesulphonate in the form of a pale yellow solid.

Provenance & Evidence