p-Toluenesulfonic acid monohydrate → HCID 86756912, compound

Participants

Reaction Steps

A solution of 0.363 g of (E)-2(R)-([1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-isobutyl-4-methyl-2′-[2-(1-pyrrolidinyl)acetyl]valerohydrazide in 5 ml of methanol was treated with 0.133 g of p-toluenesulphonic acid monohydrate. The mixture was stirred for 4 hours at room temperature and evaporated. The residue was triturated with diethyl ether, filtered off and dried to give 0.317 g of (E)-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenyl-3-butenyl]-2′-isobutyl-4-methyl-2′-[2-(1-pyrrolidinyl)acetyl]valerohydrazide p-toluenesulphonate in the form of a white solid.

Provenance & Evidence