HCID 86756932, compound → HCID 86756931, compound

Participants

Reaction Steps

A solution of 0.216 g of (E)-2(R)-[1(S)-(benzyloxycarbamoyl)-4-phenyl-3-butenyl]-2′-(4-benzyloxycarbonylaminobutyryl)-4-methyl-2′-(2(S)-methylbutyl)valerohydrazide in 5 ml of methanol was hydrogenated in the presence of 0.1 g of 10% palladium-on-carbon catalyst for 1 hour. The catalyst was removed by filtration and the methanol was evaporated. The residue was re-evaporated from diethyl ether and then triturated with a mixture of diethyl ether and hexane and there was obtained 0.104 g of 2′-(4-aminobutyryl)-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenylbutyl]-4-methyl-2′-(2(S)-methylbutyl)valerohydrazide in the form of a white solid.

Provenance & Evidence