HCID 86756962, compound → HCID 86756961, compound

Participants

Reaction Steps

A solution of 0.130 g of 2(R)-[1(S)-(N-benzyloxycarbamoyl)-4-cyclopentylbutyl]-2′-isobutyl-2′-[2-(imidazoyl)acetyl]-4-methylvalerohydrazide in 3 ml of methanol was hydrogenated in the presence of 0.040 g of 5% palladium-on-carbon for 4 hours. Filtration and evaporation gave a residue which was triturated with diethyl ether. Filtration gave 0.083 g of 2(R)-[4-cyclopentyl-1(S)-(hydroxycarbamoyl)butyl]-2′-isobutyl-2′-[2-(imidazoyl)acetyl]-4-methylvalerohydrazide in the form of a white solid.

Provenance & Evidence