p-Toluenesulfonic acid monohydrate → HCID 86756963, compound

Participants

Reaction Steps

A solution of 0.180 g of (E)-2′-(D-alanyl)-2(R)-[1(RS)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-(2-thienyl)-3-butenyl]-2′-isobutyl-4-methylvalerohydrazide in 5 ml of methanol was treated with 0.077 g of p-toluenesulphonic acid monohydrate. The mixture was stirred at room temperature for 2 hours and evaporated. The residue was purified by column chromatography on silica gel, using dichloromethane/methanol (95:5) for the elution, to give 0.056 g of (E)-2′-(D-alanyl)-2(R)-[1(RS)-(hydroxycarbamoyl)-4-(2-thienyl)-3-butenyl]-2′-isobutyl-4-methylvalerohydrazide in the form of an off-white solid.

Provenance & Evidence