HCID 86756973, compound → HCID 86756972, compound

Participants

Reaction Steps

A solution of 0.420 g of 2(R)-[3-benzamido-1(S)-(benzyloxycarbamoyl)propyl]-2′-[2-(1H-imidazol-1-yl)acetyl]-2′-isobutyl-4-methylvalerohydrazide in 5 ml of methanol was hydrogenated in the presence of 0.126 g of 5% palladium-on-carbon for 12 hours. The catalyst was removed by filtration and the solvent was evaporated. The residue was triturated with diethyl ether to give 0.304 g of 2(R)-[3-benzamido-1(S)-(hydroxycarbamoyl)propyl]-2′-[2-(1H-imidazol-1-yl)acetyl]-2′-isobutyl-4-methylvalerohydrazide in the form of a white solid.

Provenance & Evidence