HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 21201812, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Pivaloyl chloride | HCID 62493 | — |
| Reactant | 3-Tert-butoxycarbonylamino-1,3,4,5-tetrahydrobenzo[b][1,4]diazepin-2-one | HCID 15490831 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | HCID 21201812 | HCID 21201812 | 71.2% |
Reaction Steps
2-Oxo-3-tert-butoxycarbonylamino-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine (700 mg) obtained from Reference Example 1 was suspended in 1,2-dichloroethane (20 ml). Pyridine (237 mg) and pivaloyl chloride (362 mg) were added thereto, and the mixture was refluxed for two hours. After the reaction mixture was allowed to cool, crystals that precipitated were collected by filtration, to thereby obtain 650 mg of the title compound (yield: 71%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06239131B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-7c211c1611bb4c4b882f1b8abed6b73c |
| Source note | uspto-grants-2001_05 |