HCID 21201739, compound → HCID 21201969, compound

HRID 1979305Notes

Reaction equation

[C:1]1([CH3:38])[C:2]([C:7]([CH2:9][N:10]2[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[N:14]([C:21](=[O:28])[C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:13][CH:12]([NH:29]C(OC(C)(C)C)=O)[C:11]2=[O:37])=[O:8])=[CH:3][CH:4]=[CH:5][CH:6]=1.C(C(CN1C2C=CC=CC=2N(C(=O)C(C)(C)C)CC(NC(OC(C)(C)C)=O)C1=O)=O)(C)(C)C>>[C:1]1([CH3:38])[C:2]([C:7]([CH2:9][N:10]2[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[N:14]([C:21](=[O:28])[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH2:13][CH:12]([NH2:29])[C:11]2=[O:37])=[O:8])=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

Reactant 2

HCID 21201739HCID 21201739, compound

HCID 21201878HCID 21201878, compound

Product 1

HCID 21201969HCID 21201969, compound

Procedure

Step 2 of Example 10 was repeated except that 1-(2-toluoylmethyl)-2-oxo-3-tert-butoxycarbonylamino-5-benzoyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine that obtained from Step 2 of Example 22 was used instead of 1-tert-butylcarbonylmethyl-2-oxo-3-tert-butoxycarbonylamino-5-pivaloyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine, to thereby obtain the title compound.

Workup

customthat obtained from Step 2 of Example 22

Sources & evidence

ORD record: ord-c419a3a5186b4f9ea14a4ff9d00e6ccf
Source dataset: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06239131B1

Reaction notes

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