Cyclohexyl isocyanate → HCID 21201915, compound

Participants

Reaction Steps

Cyclohexyl isocyanate (363 mg) was added to a solution of 2-oxo-3-tert-butoxycarbonylamino-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine (800 mg) in tetrahydrofuran (50 ml), the mixture was refluxed for 2 days. The reaction mixture was concentrated under reduced pressure, the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=1:1), to thereby obtain 790 mg of the title compound (Yield: 68%).

Provenance & Evidence