Potassium Carbonate → HCID 21201820, compound

Participants

Reaction Conditions

Reaction Steps

2-Oxo-3-benzyloxycarbonylamino-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine (1.38 g) was dissolved in N,N-dimethylformamide (20 ml), iodobenzene (1.36 g), copper powder (286 mg), copper iodide (446 mg) and potassium carbonate (622 mg) were added, the mixture was stirred at 150° C. for 2 hours. The insoluble material was removed by filtration, the filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=2:1), to thereby obtain 1.00 g of the title compound.

Provenance & Evidence