HCID 21201804, compound → HCID 21202008, compound

HRID 1979318Notes

Reaction equation

HRID 1979318 reaction equation
C([O:8][C:9]([CH2:11][N:12]1[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2[N:16]([C:23](=[O:28])[C:24]([CH3:27])([CH3:26])[CH3:25])[CH2:15][CH:14]([NH:29][C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])[C:13]1=[O:37])=[O:10])C1C=CC=CC=1>CO.[C].[Pd]>[O:37]=[C:13]1[N:12]([CH2:11][C:9]([OH:10])=[O:8])[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2[N:16]([C:23](=[O:28])[C:24]([CH3:26])([CH3:27])[CH3:25])[CH2:15][CH:14]1[NH:29][C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31]

Participants

4

Reactant 1

HCID 21201804HCID 21201804, compound

Product 1

HCID 21202008HCID 21202008, compoundYield 99.6%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

10% Palladium carbon (300 mg) was added to a suspension of 1-benzyloxycarbonylmethyl-2-oxo-3-tert-butoxycarbonylamino-5-pivaloyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine (3.0 g) in methanol (100 ml), the mixture was stirred for 30 minutes under hydrogen atmosphere. The reaction mixture was filtrated and the filtrate was concentrated under reduced pressure. Isopropyl ether was added to the residue for trituration and filtrated, to thereby obtain 2.46 g of the title compound (Yield: 99.6%) as pale yellow powder.

Workup

  1. filtrationThe reaction mixture was filtrated
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. additionIsopropyl ether was added to the residue for trituration
  4. filtrationfiltrated

Sources & evidence

ORD record
ord-33322800def345baa744cc90cfe0fb89
Source dataset
uspto-grants-2001_05
Patent number
US06239131B1

Reaction notes

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