HCID 21201899, compound → HCID 21201570, compound

Participants

Reaction Steps

Methanol (20 ml) and 10% palladium carbon (57 mg) were added to 1-(1-tert-butoxycarbonylmethyl-2-oxo-5-pivaloyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl)-3-(3-benzyloxycarbonylphenyl)urea (550 mg), the mixture was stirred at room temperature under hydrogen atmosphere for one hour. The reaction mixture was filtrated and the filtrate was concentrated under reduced pressure. Isopropyl ether was added to the residue for trituration and collected by filtration, to thereby obtain 420 mg of the title compound as a colorless solid.

Provenance & Evidence