Benzoyl chloride → HCID 21201562, compound

HRID 1979328Notes

Reaction equation

HRID 1979328 reaction equation
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O:10]=[C:11]1[NH:17][C:16]2[CH:18]=[C:19]([CH3:22])[CH:20]=[CH:21][C:15]=2[NH:14][CH2:13][CH:12]1[NH:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25].O=C1NC2C=CC=CC=2NCC1NC(OC(C)(C)C)=O>>[O:10]=[C:11]1[NH:17][C:16]2[CH:18]=[C:19]([CH3:22])[CH:20]=[CH:21][C:15]=2[N:14]([C:1](=[O:8])[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:13][CH:12]1[NH:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25]

Participants

4

Reactant 3

HCID 7412Benzoyl chlorideHCID 15490831HCID 15490831, compoundHCID 212015812-oxo-3-tert-butoxycarbonylamino-8-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine

Product 1

HCID 21201562HCID 21201562, compound

Procedure

Step 1 of Example 1 was repeated except that benzoyl chloride was used instead of pivaloyl chloride and that 2-oxo-3-tert-butoxycarbonylamino-8-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine obtained from Referential Example 4 was used instead of 2-oxo-3-tert-butoxycarbonylamino-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine, to thereby obtain the title compound.

Sources & evidence

ORD record
ord-4cba03f9717640aa8fc2b689cb14fb48
Source dataset
uspto-grants-2001_05
Patent number
US06239131B1

Reaction notes

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