Benzocaine → HCID 21201558, compound

HRID 1979329Notes

Reaction equation

HRID 1979329 reaction equation
[C:1]1([CH3:39])[C:2]([C:7]([CH2:9][N:10]2[C:16]3[CH:17]=[C:18]([CH3:21])[CH:19]=[CH:20][C:15]=3[N:14]([C:22](=[O:29])[C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH2:13][CH:12]([NH:30][C:31](OC(C)(C)C)=[O:32])[C:11]2=[O:38])=[O:8])=[CH:3][CH:4]=[CH:5][CH:6]=1.[NH2:40][C:41]1[CH:51]=[CH:50][C:44]([C:45]([O:47][CH2:48][CH3:49])=[O:46])=[CH:43][CH:42]=1>>[C:1]1([CH3:39])[C:2]([C:7]([CH2:9][N:10]2[C:16]3[CH:17]=[C:18]([CH3:21])[CH:19]=[CH:20][C:15]=3[N:14]([C:22](=[O:29])[C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH2:13][CH:12]([NH:30][C:31]([NH:40][C:41]3[CH:42]=[CH:43][C:44]([C:45]([O:47][CH2:48][CH3:49])=[O:46])=[CH:50][CH:51]=3)=[O:32])[C:11]2=[O:38])=[O:8])=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 2337BenzocaineHCID 21201825HCID 21201825, compound

Product 1

HCID 21201558HCID 21201558, compound

Procedure

Step 2 of Example 10 was repeated except that 1-(2-toluoylmethyl)-2-oxo-3-tert-butoxycarbonylamino-5-benzoyl-8-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine was used instead of 1-tert-butylcarbonylmethyl-2-oxo-3-tert-butoxycarbonylamino-5-pivaloyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine. Subsequently, Step 3 of Example 10 was repeated except that ethyl 4-aminobenzoate was used instead of ethyl 3-aminobenzoate, to thereby obtain the title compound.

Sources & evidence

ORD record
ord-e84f210b3f24457dabdfe6c22d892331
Source dataset
uspto-grants-2001_05
Patent number
US06239131B1

Reaction notes

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