Hydrochloric Acid → HCID 69692768, compound

Participants

Reaction Steps

N-(2-Aminophenyl)-N-(2-cyanoethyl)-2-fluoroaniline (6.18 g) was dissolved in ethanol (40 ml), aqueous potassium hydroxide (12.5 g) solution (80 ml) was added, the mixture was refluxed for 3 hours. The reaction mixture was allowed to cool, adjusted to pH 3 with concentrated hydrochloric acid, and extracted with methylene chloride. The organic layer was successively washed with water and saturated brine, dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure, to thereby obtain 5.6 g of the titled compound as brown amorphous (Yield: 86%).

Provenance & Evidence