HCID 21201672, compound → HCID 21201624, compound

HRID 1979352Notes

Reaction equation

HRID 1979352 reaction equation
[C:1]([C:5]([CH2:7][N:8]1[C:14]2[CH:15]=[C:16]([O:19][CH3:20])[CH:17]=[CH:18][C:13]=2[N:12]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:11][CH:10]([NH:27]C(OCC2C=CC=CC=2)=O)[C:9]1=[O:38])=[O:6])([CH3:4])([CH3:3])[CH3:2]>CO.[C].[Pd]>[C:1]([C:5]([CH2:7][N:8]1[C:14]2[CH:15]=[C:16]([O:19][CH3:20])[CH:17]=[CH:18][C:13]=2[N:12]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:11][CH:10]([NH2:27])[C:9]1=[O:38])=[O:6])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 21201672HCID 21201672, compound

Product 1

HCID 21201624HCID 21201624, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

1-tert-Butylcarbonylmethyl-2-oxo-3-benzyloxycarbonylamino-5-phenyl-8-methoxy-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine (1.11 g) was dissolved in methanol (20 ml), 10% palladium carbon (220 mg) was added, and the mixture was stirred for 2 hours under hydrogen atmosphere. Palladium carbon was removed by filtration, the filtrate was concentrated under reduced pressure, to thereby obtain 0.82 g of the titled compound as colorless amorphous(Yield: 100%).

Workup

  1. customPalladium carbon was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-611fc616c7a24032a99f07838e1d2fde
Source dataset
uspto-grants-2001_05
Patent number
US06239131B1

Reaction notes

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