1-[1-(2-Toluoylmethyl)-2-oxo-5-benzyloxycarbonyl-8-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl]-3-(3-ethoxycarbonylphenyl)urea → 1-[1-(2-toluoylmethyl)-2-oxo-8-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl]-3-(3-ethoxycarbonylphenyl)urea

Participants

Reaction Steps

1-[1-(2-Toluoylmethyl)-2-oxo-5-benzyloxycarbonyl-8-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl]-3-(3-ethoxycarbonylphenyl)urea (1.00 g) obtained from Step 4 of Example 91 was dissolved in ethanol (20 ml), 10% palladium carbon (200 mg) was added, and under hydrogen atmosphere the mixture was stirred for 2 hours and addtionally stirred for one hour at 50° C. The reaction mixture was filtrated through a pad of Celite, the filtrate was concentrated under reduced pressure, to thereby obtain 500 mg of the titled compound.

Provenance & Evidence