HCID 21201642, compound → HCID 21201731, compound

HRID 1979379Notes

Reaction equation

HRID 1979379 reaction equation
[C:1]([C:5]([CH2:7][N:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[F:25])[CH2:11][CH:10]([NH:26]C(OCC2C=CC=CC=2)=O)[C:9]1=[O:37])=[O:6])([CH3:4])([CH3:3])[CH3:2]>CO.[C].[Pd]>[C:1]([C:5]([CH2:7][N:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[F:25])[CH2:11][CH:10]([NH2:26])[C:9]1=[O:37])=[O:6])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 21201642HCID 21201642, compound

Product 1

HCID 21201731HCID 21201731, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

1-tert-Butylcarbonylmethyl-2-oxo-3-benzyloxycarbonylamino-5-(2-fluorophenyl)-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine (205 mg) was dissolved in methanol (10 ml), 10% palladium carbon (30 mg) was added, under hydrogen atmosphere the filtration, the filtrate was concentrated under reduced pressure, to thereby obtain 150 mg of the titled compound (Yield: 100%).

Workup

  1. filtrationthe filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-c61f77b07d884e27bff6750bbefd7f71
Source dataset
uspto-grants-2001_05
Patent number
US06239131B1

Reaction notes

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