反应详情

1-[1-(2-Toluoylmethyl)-2-oxo-8-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl]-3-(3-ethoxycarbonylphenyl)urea (500 mg) obtained from Step 1 of Example 93 was suspended in 1,2-dichloroethane (10 ml), 2-thienylcarbonyl chloride (157 mg) and pyridine (87 μl) were added, and the mixture was refluxed for 2 hours. Water (100 ml) and ethyl acetate (100 ml) were added, separated, the organic layer was washed with 1N hydrochloric acid, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, the residue was washed with diethyl ether, to thereby obtain 553 mg of the titled compound (Yield: 91.3%).

1. temperaturethe mixture was refluxed for 2 hours
2. customseparated
3. washthe organic layer was washed with 1N hydrochloric acid
4. dry with materialdried over anhydrous sodium sulfate
5. customThe solvent was evaporated under reduced pressure
6. washthe residue was washed with diethyl ether