Tetrahydrofuran → HCID 21201830, compound

Participants

Reaction Conditions

Reaction Steps

1-[1-(2-Thenoylmethyl)-2-oxo-5-(2-thenoyl)-8-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl]-3-(4-ethoxycarbonylphenyl)urea (1.3 g) was suspended in tetrahydrofuran (30 ml), aqueous lithium hydroxide monohydrate (0.44 g) solution (15 ml) was added, the mixture was stirred at 40-50° C. for 6 hours. The solvent was concentrated under reduced pressure, 1N hydrochloric acid and chloroform were added to the residue, crystals so precipitated were collected by filtration, washed with a mixed solvent(chloroform:methanol=10:1), and filtrated by means of suction, to thereby obtain 102 mg of the title compound.

Provenance & Evidence