HCID 21201567, compound → HCID 21201602, compound

Participants

Reaction Steps

Platinum oxide (100 mg) was added to a solution of 2-oxo-3-tert-butoxycarbonylamino-5-(2-cyclopenten-1-yl)-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine (1.8 g) in anhydrous tetrahydrofuran (20 ml), the mixture was stirred at room temperature under ambient pressure under hydrogen atmosphere for 2 hours. The reaction mixture was filtrated through a pad of Celite, the filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography(ethyl acetate:n-hexane=1:2). Diisopropyl ether was added to the residue for crystallization, to thereby obtain 1.2 g of the title compound.

Provenance & Evidence