Potassium Carbonate → HCID 21201756, compound

Participants

Reaction Steps

Bromomethyl tert-butylketone (684 mg), potassium iodide (26.4 mg), tetra n-butylammonium bromide (30.8 mg) and potassium carbonate (528 mg) were added successively to a solution of 2-oxo-3-tert-butoxycarbonylamino-5-cyclopentyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine (1.1 g) in N,N-dimethylformamide (30 ml), the mixture was stirred at room temperature for 2 hours. Ice-water was added to the reaction mixture, extracted with ethyl acetate, the organic layer was washed with saturated brine. The resultant mixture was dried over anhydrous sodium sulfate, the solvent was evaporated under reduced pressure, and n-hexane was added to the residue for crystallization, collected by filtration, to thereby obtain 1.07 g of the title compound.

Provenance & Evidence