Hydrochloric Acid → 8-aminoquinoline-5-sulfonic acid

Participants

Reaction Steps

In a 250 ml 1-neck round-bottomed flask fitted with a reflux condenser was placed 25.0 g (0.0724 m) of the pyridinium 8-acetamido-5-quinolinesulfonate and 30 ml water. The slurry was heated to effect solution, 30 ml concentrated hydrochloric acid added and the mixture heated to reflux for 1 hour with stirring. A thick crystalline mass separated during the heating period. The thick slurry was then chilled to 0°-5° C. for several hours, filtered and washed with cold 6N hydrochloric acid and THF. The yield was 11.3 g (70 percent) of product as off-white needles.

Provenance & Evidence