Water → HCID 20439405, compound

Participants

Reaction Steps

Lithium aluminium hydride (0.46 g) was added to a solution or methyl 4-methyl-5-[[1-oxo-4[3-(1-piperidinylmethyl)phenoxy]butyl]amino]-4H-1,2,4-triazole-3-carboxylate (0.58 g) in dry tetrahydrofuran (20 ml) under an atmosphere of dry nitrogen. The grey suspension was stirred at room temperature for 3.5 h before adding water (0.5 ml), 15% aqueous sodium hydroxide (1.0 ml), water (0.5 ml) and ethyl acetate (20 ml). The suspension was filtered and the filtrate was evaporated under reduced pressure to give a solid which was recrystallised from ethyl acetate (5 ml) to give the title compound as a white solid (0.04 g) m.p. 128°-30°.

Provenance & Evidence