Methanol → 1-[2-(Dimethylamino)ethyl]-3,4-dimethyl-1H-pyrrole-2,5-dione
Reaction equation
C[NH:2][CH2:3][CH2:4][NH:5][CH3:6].[CH3:7][C:8]1[C:9]([O:11][C:12](=O)[C:13]=1[CH3:14])=[O:10].[CH3:16]O>C(Cl)(Cl)Cl>[CH3:16][N:5]([CH2:4][CH2:3][N:2]1[C:9](=[O:10])[C:8]([CH3:7])=[C:13]([CH3:14])[C:12]1=[O:11])[CH3:6]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 15 °C
Procedure
A solution of 17.5 g (0.2 mol.) of asym.dimethyl ethylene diamine in 100 ml of methanol is added dropwise to a solution of 25.1 g (0.2 mol.) of 2,3-dimethyl maleic acid anhydride in 100 ml of chloroform. The mixture is stirred for one hour at 15° C. The solvents are evaporated in vacuo and the residue is recrystallised from acetone. The pure product has a melting point of 9° C. and is used in the next step (c).
Workup
- customThe solvents are evaporated in vacuo
- customthe residue is recrystallised from acetone
Sources & evidence
- ORD record
- ord-e44d75a01b7b40698879c3b51d86dc65
- Source dataset
- uspto-grants-1984_11
- Patent number
- US04481340
Reaction notes
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