HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boric Acid → 7-Amino-3-(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boric Acid | HCID 7628 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Acetoxymethyl-7-amino-3cephem-4-carboxylic acid | HCID 11346310 | — |
| Reactant | HCID 178434161 | HCID 178434161 | — |
| Solvent | Water | HCID 962 | — |
| Product | 7-Amino-3-(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid | HCID 12942034 | — |
Reaction Steps
A suspension of 40 g (0.30 mole) of 2-mercapto-5-methyl-1,3,4-thiadiazole (TD) in 3.15 liters of water, with 30 g of boric acid and 30.4 ml (≃0.217 mole) of triethylamine was heated to 70/72° C. While the mixture was being vigorously stirred, at the same temperature, one 40 g shot (0.147 mole) of 7-amino-3-acetoxymethyl-3-cephem-4-carboxylic acid (92%) was added.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04481357 |
| Source dataset | uspto-grants-1984_11 |
| ORD ID | ord-9e27d12a9e3c4b2a891a89d583a4159f |
| Source note | uspto-grants-1984_11 |