Hydrochloric Acid → HCID 88600928, compound

Participants

Reaction Steps

4.29 g (3 cmole) of 3-methylisoxazole-5-thiocarboxylic acid were dissolved in 300 ml of 60% isopropanol-water and there were added 1.6 ml of DBU (Example 9) and 3 ml of beta-picoline. At 65° C., there were added in one shot 3.0 g of 7-aminocephalosporanic acid, 90%. The mixture was stirred for 90 minutes and the reaction isoelectric pH was held to 5.5. The precipitate which formed was isolated after adjusting the pH to 4.0 at 25° C. by concentrated hydrochloric acid. The precipitate was filtered, washed with water and acetone to give 3.0 g of the compound of the title, with an 80% yield. The infrared and proton magnetic resonance spectra are consistent with its structure.

Provenance & Evidence