Acetohydrazide → HCID 178434154, compound

HRID 1979631Notes

Reaction equation

HRID 1979631 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]=[C:9]=[S:10].[C:11]([NH:14][NH2:15])(=O)[CH3:12]>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:11]([CH3:12])=[N:14][N:15]=[C:9]1[SH:10]

Participants

3

Reactant 2

HCID 14039AcetohydrazideHCID 975202-Fluorophenyl isothiocyanate

Product 1

HCID 178434154HCID 178434154, compound

Procedure

Using the method of Example 1, Part A of U.S. Pat. No. 4,338,453, 2-fluorophenyl isothiocyanate and acethydrazide are reacted to produce 4-(2-fluorophenyl)-5-methyl-4H-1,2,4-triazole-3-thiol (mp 236°-237° C., C:H:N:S:F ratio 51.69:3.86:20.10:15.84:9.10) which is converted to 4-(2-fluorophenyl)-3-methyl-4H-1,2,4-triazole (mp 119°-120° C., C:H:N:F ratio 61.28:4.83:23.58:10.42).

Sources & evidence

ORD record
ord-42b339c1eb2b40ef90970c30593954cb
Source dataset
uspto-grants-1984_11
Patent number
US04481360

Reaction notes

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