Sulfuric Acid → HCID 54061754, compound

Participants

Reaction Steps

247.5 Parts of 4-acetylaminophenyl-β-hydroxyethylsulfone (purity: 98.2%) and 205.8 parts of 50% sulfuric acid were fed into a two-shaft double-arm kneader (manufactured by Inoue Seisakusho) operated at 60 r.p.m., and the mixture was maintained at 100° to 105° C. under reduced pressure (400 mmHg) for 10 hours while distilling off the produced water and acetic acid. The reaction product was analyzed by liquid chromatography, obtaining 4-aminophenyl-β-sulfatoethylsulfone in a 96% yield, and 4-aminophenyl-β-hydroxyethylsulfone and 4-aminophenyl-β-acetoxyethylsulfone in small amounts.

Provenance & Evidence