Sulfuric Acid → HCID 86739755, compound

Participants

Reaction Steps

292.9 Parts of 2-methyl-4-acetylamino-5-methoxyphenyl-β-hydroxyethylsulfone (purity: 98%) and 500 parts of diatomaceous earth were fed into a dispersion kneader (manufactured by Inoue Seisakusho) operated at 70 r.p.m. and then 210 parts of 70% sulfuric acid (molar ratio: 1.5) were added thereto. The mixture was maintained at 95° to 100° C. under reduced pressure (300 mmHg) for 7 hours while distilling off the produced water and acetic acid. The reaction product was analyzed by liquid chromatography, obtaining 2-methyl-4-amino-5-methoxyphenyl-β-hydroxyethylsulfone in a 94% yield.

Provenance & Evidence