Sulfuric Acid → HCID 54061754, compound

Participants

Reaction Steps

2475 Parts of 4-acetylaminophenyl-β-hydroxy ethylsulfone (purity: 98.2%) were added to 1470 parts (molar ratio 1.05) of 70% sulfuric acid under stirring. The mixture was maintained at 100° to 105° C. for 1 hour and then continuously fed into a Kurimoto continuous kneader at a rate of 5 parts per minute, while distilling off the produced water and acetic acid. The powdery reaction product obtained continuously was analyzed by paper-chromatography, obtaining 4-aminophenyl-β-sulfatoethylsulfone in a 94% yield, and 4-aminophenyl-β-hydroxyethylsulfone and 4-aminophenyl-β-acetoxy-ethylsulfone in small amounts.

Provenance & Evidence