Formic Acid → HCID 13376540, compound

Participants

Reaction Steps

A stirred solution of 48.66 g (0.2 mol) of 1-[(2-nitrophenyl)methyl]-1-phenylhydrazine and 200 ml of 97% formic acid solution was heated 4 hours under reflux and allowed to stand overnight (about 16 hours) at ambient temperature. Excess formic acid was removed on a rotary evaporator and the residue was dissolved in 1500 ml of CH2Cl2. The solution was washed with 10% NaOH and concentrated to dryness. Recrystallization from 600 ml of 95% ethanol afforded 44.0 g (81.8%) of 2-formyl-1-[(2-nitrophenyl)methyl]-1-phenylhydrazine, m.p. 140°-142.5° C.

Provenance & Evidence