Hydrochloric Acid → HCID 13376557, compound

Participants

Reaction Steps

To a solution of 3.5 g (0.0154 m) of 1-[(2-aminophenyl)methyl]-2-methyl-1-phenylhydrazine of Example 9c in 40 ml of acetonitrile and 4.87 g (0.03 m) of triethyl orthoacetate was added sufficient ethereal HCl to make the solution acidic. The mixture was refluxed 5.5 hours. The solvents were evaporated and the residue was partitioned between 10% NaOH and ether. The ether extract was washed with water, dried (Na2SO4) and filtered. The product was precipitated with ethereal HCl to afford 2.63 g (60%) of 4,5-dihydro-2,3-dimethyl-4-phenyl-3H-1,3,4-benzotriazepine hydrochloride, m.p. 274°-277° C.

Provenance & Evidence