Diethyl (ethoxymethylene)malonate → HCID 12778919, compound

Participants

Reaction Conditions

Reaction Steps

42 g of 2-amino-pyrroline are dissolved in 400 ml of ethanol and at 0° to 7° C., a solution of 108 g of diethyl ethoxymethylene-malonate in 200 ml ethanol is added dropwise. After the addition is completed, the mixture is stirred for 1 hour at 0° C. and allowed to stand for 12 hours at -5° C. The precipitated crystals are filtered. After evaporation of the alcohol the residue is boiled with 200 ml of benzene. After cooling the insoluble crystals are filtered off. The filtered crystals are combined and recrystallized from ethanol. 50.3 g (48.4%) ethyl 2-oxo-2,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-3-carboxylate are obtained, melting at 193° C.

Provenance & Evidence