HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1'-Thiocarbonyldiimidazole → HCID 20438543, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1'-Thiocarbonyldiimidazole | HCID 80264 | — |
| Reactant | 1-[3-Amino-2-(2,4-dichlorophenyl)-2-hydroxyprop-1-yl]-1H-1,2,4-triazole | HCID 14706521 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 20438543 | HCID 20438543 | — |
Reaction Steps
A solution of the amine (A) (1 g, 3.48 mmole) and 1,1'-thiocarbonyldiimidazole (0.62 g, 3.48 mmole) in tetrahydrofuran (20 ml) was stirred at room temperature for one hour. The solvent was then evaporated and the residue was chromatographed on silica (230-400 mesh), eluting with ethyl acetate. One recrystallization from ethanol gave the pure title compound, 0.65 g (57%), as a white solid, m.p. 232°-235° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04482558 |
| Source dataset | uspto-grants-1984_11 |
| ORD ID | ord-23b41793dcd54c64abad5d071a965712 |
| Source note | uspto-grants-1984_11 |