反应详情

Polyphosphoric acid (10.0 g) is heated to 100° C. and 1.0 g of 6,7-dimethoxy-1-cyanomethylene-1,2,3,4-tetrahydroisoquinoline is added under mechanical stirring. The reaction mixture is heated for 1 hour, poured into crushed ice and made basic with 30% sodium hydroxide. The mixture is extracted with chloroform and the extract dried over anhydrous sodium sulfate. The solvent is evaporated under reduced pressure to give a white solid, yield 0.7 g, mp. 156°-158° C.

1. temperatureThe reaction mixture is heated for 1 hour
2. additionpoured
3. custominto crushed ice
4. extractionThe mixture is extracted with chloroform
5. dry with materialthe extract dried over anhydrous sodium sulfate
6. customThe solvent is evaporated under reduced pressure
7. customto give a white solid, yield 0.7 g, mp. 156°-158° C.