反应详情

温度

50 °C

69 ml of 1N sodium hydroxide and 7.3 ml of epichlorohydrin were added to a solution of 7.2 g of 2-(2-hydroxyphenoxy)ethanol in 50 ml of dioxane, and the mixture was heated at 50° C. for 2 hours with stirring. The reaction solution was extracted with chloroform, washed with water and dried. The solvent was distilled off under reduced pressure. The residue was chromatographed on a silica gel column to afford 4.1 g (yield 41.7%) of 1,2-epoxy-3-[2-(2-hydroxyethoxy)phenoxy]propane as a colorless oil.

1. extractionThe reaction solution was extracted with chloroform
2. washwashed with water
3. customdried
4. distillationThe solvent was distilled off under reduced pressure
5. customThe residue was chromatographed on a silica gel column