HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1979751Generated: October 25, 2026
1-Methyl-3-phenylpropylamine → 1-[4-Methoxy-3-[2-(tetrahydro-2-pyranyloxy)ethoxy]phenyl]-2-(1-methyl-3-phenylpropyl)aminoethanol
https://huagongshe.com/reaction/1979751
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Methyl-3-phenylpropylamine | HCID 31160 | — |
| Reactant | 4-Methoxy-3-[2-(tetrahydro-2-pyranyloxy)ethoxy]styrene oxide | HCID 20438896 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-[4-Methoxy-3-[2-(tetrahydro-2-pyranyloxy)ethoxy]phenyl]-2-(1-methyl-3-phenylpropyl)aminoethanol | HCID 20438893 | 34.9% |
Reaction Steps
14.7 g of 4-methoxy-3-[2-(tetrahydro-2-pyranyloxy)ethoxy]styrene oxide was dissolved in 770 ml of ethanol, and 55 g of 4-phenyl-2-butylamine was added. The mixture was stirred at 90° C. for 40 minutes. After the reaction, the reaction mixture was concentrated under reduced pressure, and the residue was chromatographed on a silica gel column to afford 7.73 g (yield 34.9%) of 1-[4-methoxy-3-[2-(tetrahydro-2-pyranyloxy)ethoxy]phenyl]-2-(1-methyl-3-phenylpropyl)aminoethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04482562 |
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| Source dataset | uspto-grants-1984_11 |
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| ORD ID | ord-4a05edd9cc86491289b36d2a8ab6215e |
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| Source note | uspto-grants-1984_11 |
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