反应详情

35.4 Grams of 7-methoxy-3,4-dihydrocarbostyril was dissolved in 300 ml of acetic acid and under ice-cooled condition with stirring 27 g of sulfuryl chloride dissolved in 100 ml of acetic acid was added dropwise, then the reaction mixture was allowed to stand overnight. The reaction mixture was poured into 1 liter of ice water and the precipitates were obtained by filtration, washed with water, dried and recrystallized from methanol. 30 Grams of 6-chloro-7-methoxy-3,4-dihydrocarbostyril having the melting point of 212° C. was obtained as in the form of colorless needle-like crystals.

1. temperaturecooled condition
2. additionwas added dropwise
3. customthe precipitates were obtained by filtration
4. washwashed with water
5. customdried
6. customrecrystallized from methanol