反应详情

2.4 Grams of 7-(3-chloropropoxy)-3,4-dihydrocarbostyril and 4.0 g of 4-hydroxy-4-phenylpiperidine were mixed with 150 ml of toluene and heated under refluxing condition for 24 hours. After cooling the reaction mixture, the precipitates formed were collected by filtration and washed with water, then recrystallized from ethanol. 2.8 Grams of 7-[3-(4-hydroxy-4-phenyl-1-piperidyl)propoxy]-3,4-dihydrocarbostyril was obtained as in the form of colorless flake-like crystals. Melting point: 215° C.

1. temperatureheated
2. temperatureunder refluxing condition for 24 hours
3. temperatureAfter cooling the reaction mixture
4. customthe precipitates formed
5. filtrationwere collected by filtration
6. washwashed with water
7. customrecrystallized from ethanol