Triethylamine → HCID 13064794, compound

Participants

Reaction Steps

1.43 Grams of 1-methyl-6-(2-bromoethoxy)-3,4-dihydrocarbostyril, 1.3 g of 4-acetyl-4-phenylpiperidine and 1 g of triethylamine were mixed with 30 ml of dimethylformamide and the mixture was heated at 60°-70° C. for 5 hours. The reaction mixture thus obtained was concentrated under a reduced pressure to dryness, and to the residue thus obtained was added 5% sodium hydrogencarbonate aqueous solution and stirred. The insoluble matters were collected by filtration, washed with water then dried and recrystallized from ethanol-water to obtain 1.3 g of 1-methyl-6-[2-(4-acetyl-4-phenyl-1-piperidyl)ethoxy]-3,4-dihydrocarbostyril as in the form of colorless prism-like crystals. Melting point: 101°-103° C.

Provenance & Evidence