Water → HCID 54293928, compound

Participants

Reaction Steps

14 g. (0.1 mol) 2-chlorobenzaldehyde are added dropwise, at ambient temperature, to a solution of 16.7 g. (0.1 mol) diethyl aminomethylphosphonate in 200 ml. toluene. When the addition has ended, stirring is continued for 30 minutes. The water formed during the reaction is removed by decantation. The toluene phase is washed with 50 ml. of a saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulphate and then evaporated. This gives 29 g. (yield: 100%) diethyl N-(o-chlorobenzylidene)-aminomethylphosphonate in the form of a yellow oil giving a single spot in TLC (silica plate, eluant: ethyl acetate, Rf=0.45).

Provenance & Evidence