Sodium Acetate → HCID 178442485, compound

HRID 1979809Notes

Reaction equation

HRID 1979809 reaction equation
[C:1]([NH2:9])(=[NH:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].Cl[CH:11]([C:17](=[O:19])[CH3:18])[CH:12](OC)OC.C([O-])(=O)C.[Na+]>O1CCOCC1>[C:17]([C:11]1[N:8]=[C:1]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7])[NH:9][CH:12]=1)(=[O:19])[CH3:18]

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 3264451HCID 3264451, compoundHCID 155879453-Chloro-4,4-dimethoxybutan-2-one

Product 1

HCID 178442485HCID 178442485, compoundYield 42%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Repeating the above procedure with 0.20 mole of heptanamidine, 0.15 mole 2-chloro-1,1-dimethoxy-3-butanone, 0.35 mole sodium acetate in 400 ml dioxane by refluxing for six hours, allowing to stand overnight at room temperature and work-up as above, affords a 42% yield of pure product, M.P. 104°-106° C. and 26% of impure product. For the pure sample: 1H-NMR (CDCl3) ppm (delta): 0.85 (t, 3H), 1.28 (m, 7H), 1.75 (m, 2H), 2.52 (s, 3H), 2.83 (t, 2H), 7.72 (s, 1H).

Workup

  1. temperatureby refluxing for six hours

Sources & evidence

ORD record
ord-b54678c1d6304f3b99327b8750d3b026
Source dataset
uspto-grants-1984_11
Patent number
US04482723

Reaction notes

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