HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Dichloro-4-fluoroaniline → N-[(3,5-dichloro-4-fluorophenyl)-carbamoyl]-2-methylalanine methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Dichloro-4-fluoroaniline | HCID 75948 | — |
| Reactant | Methyl 2-isocyanato-2-methylpropanoate | HCID 2769374 | — |
| Product | N-[(3,5-dichloro-4-fluorophenyl)-carbamoyl]-2-methylalanine methyl ester | HCID 20439133 | — |
Reaction Steps
3-(3,5-dichloro-4-fluoro-phenyl)-5,5-dimethylhydantoin, which melts at 175°-176°, is obtained in the manner indicated in Example 1 from 3,5-dichloro-4-fluoro-aniline and 2-isocyanato-2-methylpropionic acid methyl ester and after crystallizing from ether/petroleum ether. The N-[(3,5-dichloro-4-fluorophenyl)-carbamoyl]-2-methylalanine methyl ester intermediately formed is not isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04482739 |
| Source dataset | uspto-grants-1984_11 |
| ORD ID | ord-4fe010b0c4594114b2aea3f95cd1b75c |
| Source note | uspto-grants-1984_11 |