2-Amino-2-methylpropionitrile → 1-(4-Chloro-3-(trifluoromethyl)phenyl)-5-imino-4,4-dimethyl-4,5-dihydro-1H-imidazol-2-ol

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Reaction Steps

14.5 g. of 3-trifluoromethyl-4-chlorophenyl-isocyanate and 5.5 g. of α-aminoisobutyronitrile are kept at 100° for 20 minutes. For purification, the viscous oil obtained is chromatographed on 500 g. of silica gel (particle size about 0.06-0.2 mm) using methylene chloride/methanol. The product obtained is crystallized from methylene chloride/petroleum ether. After drying under greatly reduced pressure at 50° for 15 hours, 1-(3-trifluoromethyl-4-chlorophenyl)-5-imino-4,4-dimethyl-2-imidazolidinone, which melts at 148°-149°, is obtained.

Provenance & Evidence