反应详情

温度

95 °C

3-Ethyl-1-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene (94 g, 0.405 mol) was stirred with glacial acetic acid (670 mL), and hexamethylenetetramine (102.6 g, 0.73 mol) was added in one portion. The mixture was heated at 95° C. for 3 h, hot water (670 mL) added, and the heating was continued for an additional 1.5 h at 100° C. The mixture was cooled to 20° C., toluene (200 mL) was added, and the mixture was stirred vigorously. The organic layer was separated, washed with water (3×150 mL), then neutralized with 5% NaHCO3 solution, and finally washed with brine (50 mL). The solvent was evaporated and the residue distilled to give 3-ethyl-1-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carboxaldehyde (77.9 g), bp 127°-132° C./0.5 mm, GLC purity 98%, exhibiting the expected spectral data.

1. additionwas added in one portion
2. temperatureThe mixture was cooled to 20° C.
3. customThe organic layer was separated
4. washwashed with water (3×150 mL)
5. washfinally washed with brine (50 mL)
6. customThe solvent was evaporated
7. distillationthe residue distilled