HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azepane → 3-Azepan-1-ylpropan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azepane | HCID 8119 | — |
| Reactant | 3-Chloro-1-propanol | HCID 12313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Azepan-1-ylpropan-1-ol | HCID 10558885 | 88% |
Reaction Steps
A solution of 1 mole of azepane and 0.5 mole of 3-chloro-1-propanol in 500 ml of ethanol was refluxed for 18 hours. The reaction mixture was treated with 0.55 mole of KOH and refluxed for 0.75 hour. Cooling, filtration and distillation yielded 88% of N-(3-hydroxypropyl)azepane (b.p.=136° C. at 21 mm; analysis for C9H19NO, calculated: %N=8.91; found: %N=8.30).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04483833 |
| Source dataset | uspto-grants-1984_11 |
| ORD ID | ord-8f3aa081a5ea49de891125a45b7c7581 |
| Source note | uspto-grants-1984_11 |