HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Hexanedione → 3-(2,5-Dimethylpyrrolidin-1-yl)propan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Hexanedione | HCID 8035 | — |
| Reactant | 3-Amino-1-propanol | HCID 9086 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(2,5-Dimethylpyrrolidin-1-yl)propan-1-ol | HCID 102712 | 36% |
Reaction Steps
A total of 3 moles of 2,5-hexanedione, 3 moles of 3-amino-1propanol, 10 g of 10% Pd/C, and 500 ml of ethanol were charged to an autoclave. The reaction mixture was pressured up to 1100 psi of H2 and kept for 3 hours at 100° C. Distillation yielded 170 g of N-(3-hydroxypropyl)-2,5-dimethylpyrrolidine (b.p.=119° C. at 25 mm).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04483833 |
| Source dataset | uspto-grants-1984_11 |
| ORD ID | ord-9b81856340254beda417e4d710f7b50b |
| Source note | uspto-grants-1984_11 |