Ethanol → 3-(2,4-dichlorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butyrimidic acid, ethyl ester dihydrochloride

HRID 1979920Notes

Reaction equation

HRID 1979920 reaction equation
[C:1]([CH2:3][C:4]([C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=1[Cl:19])([OH:11])[CH2:5][N:6]1[CH:10]=[N:9][CH:8]=[N:7]1)#[N:2].[CH2:20]([OH:22])[CH3:21]>>[ClH:18].[ClH:18].[Cl:19][C:13]1[CH:14]=[C:15]([Cl:18])[CH:16]=[CH:17][C:12]=1[C:4]([OH:11])([CH2:5][N:6]1[CH:10]=[N:9][CH:8]=[N:7]1)[CH2:3][C:1](=[NH:2])[O:22][CH2:20][CH3:21]

Participants

3

Reactant 2

HCID 702EthanolHCID 133903931-Cyano-2-(2,4-Dichlorophenyl)-3-(1H-1,2,4-triazol-1-yl)-2-propanol

Product 1

HCID 1317139683-(2,4-dichlorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butyrimidic acid, ethyl ester dihydrochloride

Procedure

1-Cyano-2-(2,4-dichlorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol (1 g) was dissolved in dry ethyl alcohol (100 ml) and dry hydrogen chloride gas was bubbled in, at 0° C., for 10 minutes. The reaction mixture was then stirred at room temperature overnight, and then the solvent was decanted from the solid. The solid was then washed with dry ether and dried to yield the title compound, (1.15 g), m.p. 154°-156° C. Found: C,40.6; H,4.4; N,13.6. Calculated for C14H16Cl2N4O2.2HCl: C,40.4; H,4.4; N,13.5%.

Workup

  1. customdry hydrogen chloride gas was bubbled in, at 0° C.
  2. customthe solvent was decanted from the solid
  3. washThe solid was then washed with dry ether
  4. customdried

Sources & evidence

ORD record
ord-bf4fb9e6fa6248619f252880faee6cf4
Source dataset
uspto-grants-1984_11
Patent number
US04483863

Reaction notes

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