HCID 20437722, compound → 2,4-Diethoxy-6-(1-piperazinyl)-1,3,5-triazine

HRID 1979937Notes

Reaction equation

HRID 1979937 reaction equation
[CH2:1]([O:3][C:4]1[N:9]=[C:8]([O:10][CH2:11][CH3:12])[N:7]=[C:6]([N:13]2[CH2:18][CH2:17][N:16](C=O)[CH2:15][CH2:14]2)[N:5]=1)[CH3:2]>[OH-].[K+].C(O)C>[CH2:1]([O:3][C:4]1[N:9]=[C:8]([O:10][CH2:11][CH3:12])[N:7]=[C:6]([N:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[N:5]=1)[CH3:2]

Participants

4

Reactant 1

HCID 20437722HCID 20437722, compound

Product 1

HCID 204377152,4-Diethoxy-6-(1-piperazinyl)-1,3,5-triazineYield 102.5%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14797Potassium HydroxideSolvent2×

Procedure

The product from (b) (3.25 g) in potassium hydroxide solution (1N, 20 ml) and ethanol (30 ml) was left at room temperature for 3 hours. Then further potassium hydroxide solution (20 ml) was added. After 45 minutes the reaction mixture was extracted with chloroform (5×30 ml), and the combined chloroform extracts dried (Na2SO4) and evaporated in vacuo to give 4,6-diethoxy-2-piperazino-1,3,5-triazine (3.0 g) as an oil. The product was characterized spectroscopically and used directly without further purification.

Workup

  1. extractionAfter 45 minutes the reaction mixture was extracted with chloroform (5×30 ml)
  2. dry with materialthe combined chloroform extracts dried (Na2SO4)
  3. customevaporated in vacuo

Sources & evidence

ORD record
ord-950ab7042c1143b7ba9232604171f332
Source dataset
uspto-grants-1984_11
Patent number
US04483857

Reaction notes

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